"We believe that analyses of the Y chromosome could in the future become a useful general marker to predict the risk for men to develop cancer, added Jan Dumanski, a professor at Uppsala University."
London, April 29 - Loss of Y chromosome, says a study, could explain shorter life expectancy and higher cancer risk for men.

Researchers at Uppsala University in Sweden have shown a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.

Men who had lost the Y chromosome in a large proportion of their blood cells had a lower survival, irrespective of cause of death. We could also detect a correlation between loss of the Y chromosome and risk of cancer mortality, explained Lars Forsberg, a researcher at department of immunology, genetics and pathology at Uppsala University.

To reach this conclusion, researchers analysed the DNA in blood samples from a group of more than 1,600 elderly men.

They found that the most common genetic alteration was a loss of the Y chromosome in a proportion of the white blood cells.

The group of men was studied for several years and the researchers could detect a correlation between the loss of the Y chromosome and shorter survival.

The results indicate that the Y chromosome has a role in tumour suppression and they might explain why men get cancer more often than women.

We believe that analyses of the Y chromosome could in the future become a useful general marker to predict the risk for men to develop cancer, added Jan Dumanski, a professor at Uppsala University.

The study was published in the journal Nature Genetics.


comments powered by Disqus
Read more on:
 LONDON (80177 views)
 WOMEN (22463 views)
 RESEARCH (16031 views)
 BLOOD (11961 views)
 PROFESSOR (9541 views)
 CANCER (9541 views)
 RESULTS (7151 views)
 SWEDEN (5091 views)
 BLOOD CELL (5007 views)
 BLOOD SAMPLE (3861 views)
 GENETIC (3831 views)
 JOURNAL NATURE (3636 views)
 CANCER RISK (3018 views)
 CHROMOSOME (2667 views)
 MORTALITY (2601 views)
 BLOOD CELLS (2221 views)
 GENETICS (2176 views)
 WHITE BLOOD CELL (1944 views)
 UPPSALA UNIVERSITY (1237 views)
 NATURE GENETICS (901 views)
 PATHOLOGY (471 views)
 

PERMALINK

http://www.nerve.in/news:2535002370473
You can quote the permanent link above for a direct link to the story. We do not archive or expire our news stories.


STORY OPTIONS
  Email this story to a friend
  XML feed for Europe


 
COPYRIGHTS INFORMATION
All rights reserved for news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.
Contact Nerve Staff for any feedback, corrections and omissions in news stories.
 

All rights reserved for the news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.