"This opens up new avenues for exploration while providing some comfort for those suffering from eczema, noted Mike Turner, head of infection and immunobiology at the Wellcome Trust."
London, May 6 - Even an uncomfortable skin allergy has a good side to it. If we believe researchers, eczema caused by defects in the skin could reduce the risk of developing skin cancer.

According to a study, the immune response triggered by eczema could help prevent tumour formation by shedding potentially cancerous cells from the skin.

We are excited as it establishes a clear link between cancer susceptibility and an allergic skin condition in our experimental model. It means that modifying the body's immune system is an important strategy in treating cancer, said professor Fiona Watt, director of Centre for Stem Cells and Regenerative Medicine at King's College London.

Eczema can result from the loss of structural proteins in the outermost layers of the skin, leading to a defective skin barrier.

During the study, the researchers compared the effects of two cancer-causing chemicals in normal mice and mice with the barrier defect -.

The number of benign tumours per mouse was six times lower in knock-out mice than in normal mice.

The findings suggest that defects in the epidermal barrier protected the genetically engineered mice against benign tumour formation.

Researchers found that both types of mice were equally susceptible to acquiring cancer-causing mutations.

However, an exaggerated inflammatory reaction in knock-out mice led to enhanced shedding of potentially cancerous cells from the skin.

This cancer-protective mechanism bears similarities to that which protects skin from environmental assaults such as bacteria.

I hope our study provides some small consolation to eczema sufferers - that this uncomfortable skin condition may actually be beneficial in some circumstances, Watt added.

This opens up new avenues for exploration while providing some comfort for those suffering from eczema, noted Mike Turner, head of infection and immunobiology at the Wellcome Trust.

The study, first to show that allergy caused by the skin defects could actually protect against skin cancer, was published in the journal eLife.


comments powered by Disqus
Read more on:
 LONDON (80177 views)
 RESEARCH (16031 views)
 PROFESSOR (9541 views)
 CANCER (9541 views)
 COLLEGE (8521 views)
 CTI (5667 views)
 MEDICINE (4691 views)
 SIMI (4271 views)
 GENETIC (3831 views)
 IMMUNE SYSTEM (3471 views)
 LLC (2361 views)
 TURNER (901 views)
 PROTEIN (731 views)
 

PERMALINK

http://www.nerve.in/news:2535002372075
You can quote the permanent link above for a direct link to the story. We do not archive or expire our news stories.


STORY OPTIONS
  Email this story to a friend
  XML feed for Europe


 
COPYRIGHTS INFORMATION
All rights reserved for news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.
Contact Nerve Staff for any feedback, corrections and omissions in news stories.
 

All rights reserved for the news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.