"Because the nanoparticle has a core shell structure, the researchers can vary its exterior coating and compare the efficiency of tumour targeting and internalisation."
New York, June 9 - In a major breakthrough, scientists have designed nanoparticles that can deliver drugs directly to a tumour.

But what makes it special is that those nanoparticles that do not hit their target can be broken down and eliminated easily.

The nanoparticle is encased in a shell coated with a peptide that enables it to target tumour cells.

The disassembly is an interesting concept for creating drugs that respond to a certain stimulus, said Gary Braun, a post-doctoral associate in the Ruoslahti Lab at University of California, Santa Barbara.

It also minimises the off-target toxicity by breaking down the excess nanoparticles so that they can then be cleared through the kidneys, he added.

The method for removing nanoparticles unable to penetrate target cells is unique.

By focusing on the nanoparticles that actually got into cells, we can then understand which cells were targeted and study the tissue transport pathways in more detail, Braun explained.

Some drugs are able to pass through the cell membrane on their own, but many drugs, especially RNA and DNA genetic drugs, are charged molecules that are blocked by the membrane.

These drugs must be taken in through endocytosis, the process by which cells absorb molecules by engulfing them.

This typically requires a nanoparticle carrier to protect the drug and carry it into the cell, Braun noted.

And that is what we measured - the internalisation of a carrier via endocytosis, he said.

Because the nanoparticle has a core shell structure, the researchers can vary its exterior coating and compare the efficiency of tumour targeting and internalisation.

The findings appeared in the journal Nature Materials.


comments powered by Disqus
Read more on:
 

PERMALINK

http://www.nerve.in/news:2535002380107
You can quote the permanent link above for a direct link to the story. We do not archive or expire our news stories.


STORY OPTIONS
  Email this story to a friend
  XML feed for Americas


 
COPYRIGHTS INFORMATION
All rights reserved for news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.
Contact Nerve Staff for any feedback, corrections and omissions in news stories.
 

All rights reserved for the news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.