"We have found a way to stop the movement of embryonic cells by blocking LPA signals. This suggests a promising alternative in which cancer treatments might work in the future, said professor Roberto Mayor from UCL's cell and developmental biology."
New York, July 8 - For your knowledge, our cells can change into an invasive, liquid-like state to readily navigate the narrow channels in our body.

This transformation is triggered by chemical signals that, if blocked, can stop cancer cells from spreading.

This fresh insight into how cells move through the body could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumours, researchers from University of California, Los Angeles, have claimed.

Most cancer deaths are not owing to primary tumours but to secondary tumours in vital organs caused by cells moving from the original tumour to other places in the body.

Researchers used embryonic cells to investigate how groups of cells move in a developmental process similar to that used by cancer to spread around the body.

The team report a molecule called lysophosphatidic acid (LPA) changes cells from a solid-like to a liquid-like state, allowing cells to flow between normal tissues in the body.

Scientists were able to switch off the signals from LPA, stopping the cells from moving down narrow, blood vessel-like channels.

We have found a way to stop the movement of embryonic cells by blocking LPA signals. This suggests a promising alternative in which cancer treatments might work in the future, said professor Roberto Mayor from UCL's cell and developmental biology.

The research was published in the Journal of Cell Biology.


comments powered by Disqus
Read more on:
 

PERMALINK

http://www.nerve.in/news:2535002386672
You can quote the permanent link above for a direct link to the story. We do not archive or expire our news stories.


STORY OPTIONS
  Email this story to a friend
  XML feed for Americas


 
COPYRIGHTS INFORMATION
All rights reserved for news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.
Contact Nerve Staff for any feedback, corrections and omissions in news stories.
 

All rights reserved for the news content. Reproduction, storage or redistribution of Nerve content and articles in any medium is strictly prohibited.