5 years ago
Researchers explore new driver of transplant rejection: Platelets

Platelets, tiny and relatively uncharted tenants of the bloodstream known mostly for their role in blood clotting, turn out to also rally sustained immune system inflammatory responses that play a critical role in organ transplant rejection, according to a new report from Johns Hopkins scientists. Platelets potentially hold sway over many aspects of transplant biology, says Craig Morrell, D...

6 years ago
New treatment for psoriasis is safe and effective

A new treatment for moderate to severe plaque psoriasis has proven safe and effective in a phase III trial. There is also an almost linear relationship between drug dose and response, suggesting that patients can be more accurately dosed to achieve a clinical response while minimizing the risk of side-effects. These are the conclusions of authors of an Article in this week's edition of The Lancet...

7 years ago
International autoimmunity research initiative gains major support

The National Institute of Allergy and Infectious Diseases (NIAID) has renewed support, with major funding, for an ambitious seven-year-old international research consortium that is pioneering novel strategies for studying and testing new drugs and therapies against autoimmune diseases, organ transplant rejection, asthma and allergic diseases. The Immune Tolerance Network (ITN), headquarter...

7 years ago
Computing catches up with theory

PROVIDENCE, R.I. -- Good science requires great patience. In many fields, ideas and theories surge ahead while the tools to test them can take decades to catch up. When Pe-ter Richardson began talking with colleagues who were modeling blood flow through the vessels on the heart's surface, he hardly suspected that the collaboration would lead to a test of ideas he had proposed over 30 years earlier...

7 years ago
Penn researchers provide insights into how the immune system avoids attacking itself

(Philadelphia, PA) -- A finding by University of Pennsylvania School of Medicine researchers about how immune cells decide to become active or inactive may have applications in fighting cancerous tumors, autoimmune diseases, and organ transplant rejection. Pathology and Laboratory Medicine Professor Gary A. Koretzky, MD, PhD, director of the Signal Transduction Program at Penn's Abramson Family Ca...

8 years ago
Hopes raised for effectiveness of multiple sclerosis drug

A research team led by the University of Cincinnati's Bibiana Bielekova, MD, report new insights into the role of the MS drug daclizumab (Zenapax) in the March 27 online version of the Proceedings of the National Academy of Sciences. The article will appear in print April 11. The exact cause of MS is unknown, but one theory is that it may it be triggered by exposure to a viral infection or ...

8 years ago
Scientists directly view immune cells interacting to avert autoimmunity

The technique, known as two-photon laser-scanning microscopy, was able to focus deep within the lymph node of a diabetic mouse, allowing the researchers to show that immune cells known as T regulatory, or Treg, cells control the destructive action of rogue autoimmune cells when each of the two cell types interact with a third kind of cell. The role of the third cell type -- the antigen-pres...

9 years ago
NIH funds new bioinformatics resources at UT Southwestern

The contracts were awarded by the National Institute of Allergy and Infectious Disease, part of the NIH, with $8.7 million designated for UT Southwestern. The contracts will create separate bioinformatics resources – the BioHealthBase Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Diseases, and the Immunology Database and Analysis Portal (ImmPort). Each...

10 years ago
Insight into transplant rejection might lead to novel prevention therapies

Drugs targeting the immune reaction could help combat early lung rejection and its complications, thereby increasing patients' chances of survival following the surgery, the researchers said. Lung transplant recipients with particular variants of a gene called TLR4, which is critical in the lung's defense against bacterial infection, were significantly less likely to suffer acute rejection ...

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